Born and raised in Odense, Denmark, Jorgensen made his home in the United States for over 45 years. Best known for his work with Atlantic salmon flies, Jorgensen was also a talented and innovative tier of salt flies, ultra-realistic flies, bass bugs, and trout flies. He taught angling, authored books, lectured, and produced videos until his death.
In 1969 at age 44, Jorgensen left his engineering job and made fly tying his full-time profession. In 1973 he published his first book, Dressing Flies for Fresh and Salt Water. He has since authored five additional works including his famous Salmon Flies, Their Character, Style and Dressing. In 1980 on his way home to Baltimore from a fishing trip in New Hampshire he passed through Roscoe, New York, and spotted a small fishing cottage for rent. He made his home in that cottage on the banks of the Willowemoc until his death.